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Your hands, up close, are
anything but smooth.
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With peaks and valleys, folds and rifts,
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there are plenty of hiding places
for a virus to stick.
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If you then touch your face,
the virus can infect you.
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But there are two extraordinarily simple
ways you can keep that from happening:
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soap and water, and hand sanitizer.
So which is better?
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The coronavirus that causes COVID-19
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is one of many viruses whose protective
outer surface is made of a lipid bilayer.
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These lipids are pin shaped molecules
whose heads are attracted to water,
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and tails are repulsed by it.
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So in water-rich environments, lipids
naturally form a shell like this,
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with the heads outside
and the tails inside.
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Their shared reaction to water makes
the lipids stick loosely together—
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this is called the hydrophobic effect.
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This outer structure helps the molecular
machinery of the virus
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break through cellular membranes
and hijack our cells.
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But it has thousands upon thousands
of weak points
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where the right molecules
could pry it apart.
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And this is where soap comes in.
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A single drop of any brand of soap
contains quadrillions of molecules
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called amphiphiles, which resemble
biological lipids.
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Their tails, which are similarly repulsed
by water,
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compete for space with the lipids that
make up the virus’s shell.
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But they’re just different enough to break
up the regularity of the virus’s membrane,
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making the whole thing come crashing down.
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Those amphiphiles then form bubbles of
their own around particles
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including the virus’s RNA and proteins.
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Apply water, and you’ll wash that
whole bubble away.
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Hand sanitizers work less like a crowbar,
and more like an earthquake.
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When you surround a coronavirus with
water,
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the hydrophobic effect gives the bonds
within the membrane their strength.
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That same effect also holds the big
proteins
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that form coronavirus’s spikes in place
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and in the shape that enables
them to infect your cells.
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If you dry the virus out in air,
it keeps its stability.
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But now surround it with a high
concentration of an alcohol,
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like the ethanol or isopropanol found in
most hand-sanitizers.
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This makes the hydrophobic
effect disappear,
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and gives the molecules room to
move around.
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The overall effect is like removing all of
the nails and mortar from a house
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and then hitting it with an earthquake.
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The cell’s membrane collapses
and those spike proteins crumble.
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In either method, the actual process of
destroying the virus
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happens in just a second or two.
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But doctors recommend at least 20
seconds of hand-washing
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because of the intricate landscape
that is your hand.
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Soap and sanitizer need to get everywhere,
including your palms, fingertips,
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the outsides of your hands, and between
your fingers, to protect you properly.
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And when it comes to a
coronavirus outbreak,
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doctors recommend washing your hands
with soap and water whenever possible.
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Even though both approaches are similarly
effective at killing the virus,
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soap and water has two benefits:
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first it washes away any dirt which
could otherwise hide virus particles.
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But more importantly,
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it’s simply easier to fully cover your
hands with soap and water for 20 seconds.
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Of course, hand sanitizer is more
convenient to use on the go.
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In the absence of a sink, use the
sanitizer as thoroughly as possible
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and rub your hands together
until they’re dry.
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Unfortunately, there are billions of
people
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who don’t have access to clean
drinking water,
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which is a huge problem at any time
but especially during an outbreak.
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Researchers and aid groups are working to
provide solutions for these communities.
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One example is a device that uses salt,
water, and a car battery
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to make chlorinated water that kills
harmful pathogens
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and is safe for hand-washing.
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So wherever possible, soap and water are
recommended for a coronavirus,
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but does that mean it's best for every
viral outbreak?
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Not necessarily.
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Many common colds are caused by
rhinoviruses
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that have a geometric protein structure
called a capsid
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instead of a lipid membrane.
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The capsid doesn't have nearly as many
weak points
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where soap amphiphiles can pry it apart,
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so it takes longer for
soap to be effective.
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However some of its surface
proteins are still vulnerable
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to the destabilizing effect
of hand sanitizer.
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In this and similar cases, hand sanitizer
may be more effective,
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especially if you then wash your
hands to remove residual particles.
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The best way to know which to
use for any given outbreak
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is to do what's best for all
things illness-related:
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follow the advice of accredited
medical professionals.