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Which is better: Soap or hand sanitizer? - Alex Rosenthal and Pall Thordarson

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    Your hands, up close, are
    anything but smooth.
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    With peaks and valleys, folds and rifts,
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    there are plenty of hiding places
    for a virus to stick.
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    If you then touch your face,
    the virus can infect you.
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    But there are two extraordinarily simple
    ways you can keep that from happening:
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    soap and water, and hand sanitizer.
    So which is better?
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    The coronavirus that causes COVID-19
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    is one of many viruses whose protective
    outer surface is made of a lipid bilayer.
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    These lipids are pin shaped molecules
    whose heads are attracted to water,
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    and tails are repulsed by it.
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    So in water-rich environments, lipids
    naturally form a shell like this,
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    with the heads outside
    and the tails inside.
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    Their shared reaction to water makes
    the lipids stick loosely together—
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    this is called the hydrophobic effect.
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    This outer structure helps the molecular
    machinery of the virus
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    break through cellular membranes
    and hijack our cells.
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    But it has thousands upon thousands
    of weak points
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    where the right molecules
    could pry it apart.
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    And this is where soap comes in.
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    A single drop of any brand of soap
    contains quadrillions of molecules
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    called amphiphiles, which resemble
    biological lipids.
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    Their tails, which are similarly repulsed
    by water,
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    compete for space with the lipids that
    make up the virus’s shell.
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    But they’re just different enough to break
    up the regularity of the virus’s membrane,
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    making the whole thing come crashing down.
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    Those amphiphiles then form bubbles of
    their own around particles
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    including the virus’s RNA and proteins.
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    Apply water, and you’ll wash that
    whole bubble away.
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    Hand sanitizers work less like a crowbar,
    and more like an earthquake.
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    When you surround a coronavirus with
    water,
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    the hydrophobic effect gives the bonds
    within the membrane their strength.
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    That same effect also holds the big
    proteins
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    that form coronavirus’s spikes in place
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    and in the shape that enables
    them to infect your cells.
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    If you dry the virus out in air,
    it keeps its stability.
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    But now surround it with a high
    concentration of an alcohol,
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    like the ethanol or isopropanol found in
    most hand-sanitizers.
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    This makes the hydrophobic
    effect disappear,
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    and gives the molecules room to
    move around.
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    The overall effect is like removing all of
    the nails and mortar from a house
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    and then hitting it with an earthquake.
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    The cell’s membrane collapses
    and those spike proteins crumble.
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    In either method, the actual process of
    destroying the virus
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    happens in just a second or two.
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    But doctors recommend at least 20
    seconds of hand-washing
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    because of the intricate landscape
    that is your hand.
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    Soap and sanitizer need to get everywhere,
    including your palms, fingertips,
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    the outsides of your hands, and between
    your fingers, to protect you properly.
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    And when it comes to a
    coronavirus outbreak,
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    doctors recommend washing your hands
    with soap and water whenever possible.
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    Even though both approaches are similarly
    effective at killing the virus,
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    soap and water has two benefits:
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    first it washes away any dirt which
    could otherwise hide virus particles.
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    But more importantly,
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    it’s simply easier to fully cover your
    hands with soap and water for 20 seconds.
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    Of course, hand sanitizer is more
    convenient to use on the go.
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    In the absence of a sink, use the
    sanitizer as thoroughly as possible
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    and rub your hands together
    until they’re dry.
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    Unfortunately, there are billions of
    people
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    who don’t have access to clean
    drinking water,
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    which is a huge problem at any time
    but especially during an outbreak.
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    Researchers and aid groups are working to
    provide solutions for these communities.
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    One example is a device that uses salt,
    water, and a car battery
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    to make chlorinated water that kills
    harmful pathogens
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    and is safe for hand-washing.
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    So wherever possible, soap and water are
    recommended for a coronavirus,
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    but does that mean it's best for every
    viral outbreak?
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    Not necessarily.
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    Many common colds are caused by
    rhinoviruses
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    that have a geometric protein structure
    called a capsid
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    instead of a lipid membrane.
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    The capsid doesn't have nearly as many
    weak points
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    where soap amphiphiles can pry it apart,
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    so it takes longer for
    soap to be effective.
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    However some of its surface
    proteins are still vulnerable
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    to the destabilizing effect
    of hand sanitizer.
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    In this and similar cases, hand sanitizer
    may be more effective,
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    especially if you then wash your
    hands to remove residual particles.
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    The best way to know which to
    use for any given outbreak
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    is to do what's best for all
    things illness-related:
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    follow the advice of accredited
    medical professionals.
Title:
Which is better: Soap or hand sanitizer? - Alex Rosenthal and Pall Thordarson
Speaker:
Alex Rosenthal and Pall Thordarson
Description:

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Video Language:
English
Team:
closed TED
Project:
TED-Ed
Duration:
05:36

English subtitles

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